Reductive Alkylation of amines involves the formation of imine intermediates with carbonyl compounds, which on hydrogenation, result in an alkyl group being added to the amine. Also known as reductive amination of carbonyl compounds, this reaction plays an important role in specialty chemical, pharmaceutical, and medicinal chemistry. Applied Catalysts offer catalysts, services, and systems for reductive alkylation.
Reductive Alkylation
How Our Reductive Alkylation Services Help You
The reductive alkylation of amines with aldehydes under Hydrogen is another part of the process chemical toolkit to create chemically-upgraded intermediates to higher-value products. Primary amines and secondary amines can have alkyl groups added by reductive alkylation.
Pain Points We Solve
Applied Catalysts can assist you with the selection of catalysts for the selective reductive alkylation of amine substrates, run these processes at our lab and show tube scale, and deliver modular systems at commercial scale.
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Process Catalysts
Chemical Catalysts
In addition to the ACMC monolith based catalysts, Applied Catalysts can provide particulate catalysts to solve the customers catalytic needs. Applied Catalysts will provide Industry Standard catalysts when available from a number of participating Catalyst Vendors in addition to proprietary catalysts manufactured by Applied Catalysts.
Custom Catalysts
With a proven record of Custom Catalyst manufacturing services and a foundation of knowledgeable chemists and researchers, Applied Catalysts’ monolithic catalyst supports even the most challenging design and processing needs from manufacturing to development, ensuring high performance.
Applications Supported
CO2 Capture
Using an activated carbon monolith catalyst for CO2 capture has a number of advantages. First, activated carbon in the monolith can absorb and desorb CO2. Second, activated carbon is a high-capacity support for other base adsorbants, such as alkali or alkaline earth metal carbonates or amine-functionalized polymers.
Chemical Processes
ACMC catalysts can be used for continuous chemical processes, including hydrogenation of organic liquids and gases, reductive alkylation, amination, Fischer-Tropsch hydrocarbons, and oxygenates and acids, hydrochlorination, hydrodenitrogenation, and hydrodesulfurization. Our solutions are aimed at supporting activated carbon monoliths used in the chemical process.
Catalyst Processes
Hydrogenation
The hydrogenation process involves the addition of hydrogen to organic substrates. The functional groups being converted in the organic substrates can be olefinic to aliphatic groups, aromatic compounds to aliphatic compounds, nitro groups to amines, nitrile groups to amines, acids to aldehydes, and aldehydes and ketones to alcohols and ethers. Hydrogenation can also be used to remove sulfur, nitrogen, and chlorine content in molecules.
Industries Served
Pharmaceuticals
The manufacture of pharmaceuticals often contains one or more catalytic hydrogenation steps. Monolith catalysts convert the functional group of a molecule selectively into a new one to produce the starting material for the next synthetic step. Applied Catalysts can provide ACMC monolith-based catalysts for continuous flow process chemistry, enhancing the sustainability and low cost of manufacturing pharmaceutical products.
Services
APPLIED CATALYSTS CAN DEVELOP THE LAB, PILOT, AND COMMERCIAL SCALE REDUCTIVE ALKYLATION PROCESS
Here is what you can expect:
- catalysts proposed for your process based on internal or external catalyst options, including catalyst development, if needed
- lab scale proof of concept or validation testing in our lab or yours
- semi-pilot and show tube demonstrations with pilot production runs for market development
- engineering and fabrication of modular systems
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